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KMID : 0604520120380030255
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Journal of the Society of Cosmetic Scientists of Korea
2012 Volume.38 No. 3 p.255 ~ p.261
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Anti-aging Effects of Marine Natural Extracts against UVB-induced Damages in Human Skin Cells
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Lee Chan
Jang Jung-Hee
Kim Bo-Ae
Park Chan-Ik
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Abstract
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The skin is continuously exposed to environmental stresses. One of the most important stress factor is UV radiation. UV radiation causes a variety of biological effects on the skin, including inflammation, pigmentation, photoaging and cancer. Therefore in this study, we tried to search for skin-protective antioxidant materials from marine natural products (Porphyra Thalli, Laminariae japonicae thallus, Ostreae Concha, Sargassum Thallus, Undaria thallus, Haliotidis Concha, Agar, Codium thalli, Hizikia fusiforme thalli; HFE, Thalli) which exhibit protective activities against UVB-induced cytotoxicity and oxidative cell death and antiaging effects. As a results, UVB-induced cytotoxicity and cell death were effectively suppressed by treatment of Sargassum Thallus, Agar, Haliotidis Concha, Codium thalli, Thalli ethanol extracts. UVB-induced cell death was mediated by intracellular accumulation or ROS, which was significantly inhibited by treatment with marine natural products extracts. Also, The protective effect of these marine natural products seemed to be mediated by increased expression of type Ⅰ collagen and Type Ⅰ procollagen. These results suggest that marine natural products may have anti-aging effects new functional materials against oxidative stress-mediated skin damages.
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KEYWORD
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HS68 human skin fibroblast, ultraviolet B, marine natural extracts, antiaging, antioxidant
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